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Figure 3 Figure 4 4 Discussion The results of this retrospective study in our tertiary referral center show a higher risk of developing a more severe GO for men and smokers which is in concordance with many previous studies ( 4.1 Influence of biological sex on severity of GO In our retrospective analysis of a large single-center cohort female GO patients were much more common as in previous studies and similar to recent reports of tertial referral centers (PREGO III: 79.2% females vs

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None of this changes the comparison for an existing smoker, but it is exactly why the consistent advice - ours and the NHS's - is that vaping is for adult smokers and current vapers only

Despite the higher cost, nicotine salts provide a more satisfying experience for heavy smokers transitioning to vaping

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